I came to wonder...

What makes Rosetta finish a model or a particular fase of a model?

I've noticed that there can be quite a big differens in how many steps of ab initio/relax search there's conducted.

- Knorr

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The method used in Rosetta is something called Monte-Carlo method, which is to basicly do things "at random". At each step (or a set of a few steps), there's a decision to decide whether this particular model is "going somewhere", and based on a random number and the likelyhood of it going in the right direction, it will either terminate here and now, or continue going.

There's also different methods within the Rosetta application (ab initio and relax being two of those), which have different accuracy and computing time (ab initio is more precise but takes more time to calculate each step, IIRC).

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Mats

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There's also different methods within the Rosetta application (ab initio and relax being two of those), which have different accuracy and computing time (ab initio is more precise but takes more time to calculate each step, IIRC).

Full-atom relax is the stage which uses higher resolution, ab initio is the fast stage.

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