i tought how to attract more people who have a computer, and are willing to join this project.

Well solution ask a social group, like myspace friends to join.

And so if you have not joined a group allready then well why not invite your myspace friends
http://groups.myspace.com/MyspaceRosettaAtHome


the page contains verry simple information to join, no technical details at all. (i've just started to and the most complex thing so far was joining something in boinq) so i hope this will attract a lot of new people.

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sorry, I already created a myspace group a few month ago:
https://boinc.bakerlab.org/rosetta/

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If someone wants to make a good looking myspace bulletin and put it here then I'll post it

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If someone wants to make a good looking myspace bulletin and put it here then I'll post it

note that i've written this text so anybody can understand it, it is simplified
Well here i go.

Please please join Rosetta@home

What is this all about, an explaining story
Wel i hope you join the group, but there is more to it then just this myspace group, on the group page:
groups.myspace.com/MyspaceRosettaAtHome I asked you to install boinc.
If you have boinc installed you can add a project to it and that's the rosetta project. Like it is described main group page.




But what is Rosetta@home all about ?, let me try to explain.

In one line:

It is used for finding cures for diseases.



In some more lines:

DNA is a kind of bleu print for all kind of other biochemic structures. Those structures arre assembled by RNA. The way this works RNA, reads the DNA like a book, and then fabricates a rope chain of complex structures, i think these structures are also called protains, but thats a too complex word for me.

Those structure starts as kind of rope shape, but it folds up to somekind of 3 dimensional structure, like a rope-knot. This happens because some parts of the rope attract eachother, while other parts don't. The final shape makes a proteine or a virus behave to do something. And to make it a bit more complex sometimes what they look for is made of multiple rope's together.

The big problem is however, the rope can be known, but its folded endup shape is unknown. The folding part is a verry complex part. If they would use a lab it usally takes many month's of research to picture a molecule. Rosetta simulates the folding process to find the endup shape. It is still such a complex calculation that many computers are required for it, to solve this problem.


To know final rope-knot or final end shape is verry importend.

If scientist know how the structure looks like, then they can do things with it, for example if they know how some biochemics in a disease look like, then they can investigate how to make anti-bodies for it.



When you install the software and join this project then your PC helps fighting many diseases. The knots go to a public database where scientist make use of. And someday people get cured by the things we have found.



Its used for cancer, hiv, parkinson and many, many other diseas research.



What do we see on that screensaver ?

In simple words, the screen saver of the program, shows the search for the final end shape, it simulates various rope folding postions. In search for the lowest energy valeu.

The what. . . . .Lowest energy valeu ???

Well think of our rope as a spring.

A spring has only a single stable form when there is no tension on it, in other words a spring has a stable form that doesnt require energy to keep it in that stable form. And because it doesnt require it, we can call that it's "lowest energy shape". Our rope is like a long spring, and even more complex as some parts atract each other like tiny magnets, on screen you can see the program in search for this lowest energy shape of our rope in what we see as a complex simulation or calculation.

However the beaty of this simulation or calculation is that it doesnt realy make your PC slow, it starts calculating whenever the PC has nothing to do. You can still surf the web, email photoshop make music or whatever.

I hope this answers questions some of you might have as how this projects works.
And I'm hoping you will become member of this myspace group. As large groups of people often can make changes happen. At the moment mostly Artist have joined this group including me, i hope we will not stay the only frontiers of our group






It's also great if you would join this group, altough you are allready in other myspace groups, or are in other teams at rosetta@home, the point is that i hope that a large group will have that domino effect and attract others, as other people can also invite their friends this way

Good explanation,
here's my link, I don't know what happened to it a few posts earlier:
http://groups.myspace.com/rosettaathome

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Peter, I like your analogy of the spring. But you have to be careful telling people they are finding cures. I know you are trying to keep it simple. Many of us have tried to do that. But the bottom line is that it is not that simple.

If you find a vaccine that prevents people from getting a disease, you have done a great thing, but you have not "cured" the people that have it now.

If you create a tool that someone ELSE uses to develop a vaccine (note, the other BOINC projects that use Rosetta to study proteins) you have done a great thing, but still not cured anyone.

And if you study a number of docking agents and find a match, you still need extensive pharmaceutical research to actually develop a useful, safe drug.

Some of the work Rosetta is doing is directly related to developing HIV vaccines. But MOST of the work being done is theoretical research. Learning more about how proteins are formed and interact with one another. Building the tool that others will use in the future to develop drugs, vaccines, antidotes, therapies etc.

I am all for getting a simplified explanation to help bring more people in to the project. We just have to be careful that they are happy when they get here. If their understanding is that Rosetta is working on a cancer cure, they may be disappointed to find their machine working on a CAPRI, CASP, or research task. So I hope you can somehow incorporate these thoughts in to your description.

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Add this signature to your EMail:
Running Microsoft's "System Idle Process" will never help cure cancer, AIDS nor Alzheimer's. But running Rosetta@home just might!
https://boinc.bakerlab.org/rosetta/